3/4 left to right camera angle VS Over the Shoulder Shots

Cartoon scenes are most often staged with all the characters looking at each other, each drawn at a 3/4 angle.Does it make sense? When you talk to your friend, do you each look askance at each other, or do you look directly at each other?Good cartoonists like Howie Post can make it look natural - but when Saturday Morning cartoons developed fear and conservatism to the point where everyone was